1-(3-METHOXYPHENYL)CYCLOHEXANOL synthesis
- Product Name:1-(3-METHOXYPHENYL)CYCLOHEXANOL
- CAS Number:1884-42-0
- Molecular formula:C13H18O2
- Molecular Weight:206.28
36282-40-3
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Yield:1884-42-0 100%
Reaction Conditions:
Stage #1: (3-methoxyphenyl)magnesium bromide;cyclohexanone in diethyl ether at 0 - 20; for 4 h;
Stage #2: with water at 0;
Steps:
314 Description 314; 1- [3- (METHYLOXY) PHENYL] CYCLOHEXANOL (D314)
To a solution of 3-methoxyphenyl magnesium bromide (1 M in THF, 61 ml, 61 mmol, 1 equiv) at 0°C was slowly added cyclohexanone (6g, 61 mmol, 1 equiv) in ET2O (30 ML). The resulting mixture was stirred at room temperature for 4 h then poured in H2O at 0°C. The two layers were separated and the aqueous phase was extracted three times with Et2O. The combined organic phases were washed with brine, dried over MGS04 and concentrated in vacuo to give 1- [3- (METHYLOXY) PHENYL] CYCLOHEXANOL (D314) (12.4 g, 100%) as a pale yellow oil which was used in the next step without further purification.
References:
WO2004/50619,2004,A1 Location in patent:Page 74
