ChemicalBook CAS DataBase List 1-[4-(4-METHYLPIPERAZINO)PHENYL]-1-ETHANONE

1-[4-(4-METHYLPIPERAZINO)PHENYL]-1-ETHANONE synthesis

5synthesis methods

Product Name:1-[4-(4-METHYLPIPERAZINO)PHENYL]-1-ETHANONE
CAS Number:26586-55-0
Molecular formula:C13H18N2O
Molecular Weight:218.29

109-01-3 Synthesis

109-01-3
644 suppliers
$5.00/5 g

403-42-9 Synthesis

403-42-9
535 suppliers
$5.00/10g

1-[4-(4-METHYLPIPERAZINO)PHENYL]-1-ETHANONE

26586-55-0
55 suppliers
$60.00/100mg

Yield:26586-55-0 94.5%

Reaction Conditions:

at 120; for 16 h;Sealed tube;

Steps:

29.A
Example 29N-(4-(4-Fluoro-2-methoxyphenyl)pyridin-2-yl-3-(4-(4-methylpiperazin-1-yl)phenyl)butanamideStep A: Preparation of 1-(4-(4-Methylpiperazin-1-yl)phenyl)ethanone. A solution of 4-fluoro acetophenone (5.0 g, 3.6 mmol) and N-methyl piperazine (20 ml, 4 vol %) was heated in a sealed tube at 120° C. for 16 h. The reaction mixture was cooled to room temperature and poured into ice water. The precipitated solid was filtered and dried in vacuo to afford 7.50 g (94.5%) of 1-(4-(4-methylpiperazin-1-yl)phenyl)ethanone as solid.

References:

Zeitlmann, Lutz;Niestroj, Andre;Heiser, Ulrich US2011/224225, 2011, A1 Location in patent:Page/Page column 29; 30

FullText

109-01-3 Synthesis

109-01-3
644 suppliers
$5.00/5 g

403-41-8 Synthesis