1-beta-D-Arabinofuranosyluracil synthesis
- Product Name:1-beta-D-Arabinofuranosyluracil
- CAS Number:3083-77-0
- Molecular formula:C9H12N2O6
- Molecular Weight:244.2
147-94-4
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3083-77-0
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Yield:3083-77-0 99%
Reaction Conditions:
with cytidine deaminase enzyme in aq. phosphate buffer; pH=7 at 37; for 0.0833333 h;Enzymatic reaction;
Steps:
6 Comparative Example 6: Deamination of cytarabine (cytosine arabinoside) to uridine arabinoside
Comparative Example 6: Deamination of cytarabine (cytosine arabinoside) to uridine arabinoside A 100 mM solution of cytarabine (495 μΙ_) in 100 mM phosphate buffer at pH 7 was mixed with 50 μΙ_ of cytidine deaminase enzyme solution containing >300 AU in phosphate buffer. The reaction was performed at 37°C during 5 minutes and stopped with HCI. Then, the crude reaction was filtered through a 10 KDa membrane, and a portion was diluted and analyzed by HPLC-UV-DAD. The expected uridine arabinoside was identified by comparison to a standard sample, and formed in quantitative yield (>99%).
References:
INSTITUT UNIV. DE CIÈNCIA I TECNOLOGIA, S. A.;PÉREZ OZCÁRIZ, Sergio;PASCUAL GILABERT, Marta;ALONSO FERNÁNDEZ, Javier;LÓPEZ GÓMEZ, Cristina;FERNÁNDEZ FERNÁNDEZ, Carmen María;CASTELLS BOLIART, Josep WO2016/146808, 2016, A1 Location in patent:Page/Page column 30
3736-77-4
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3083-77-0
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58-96-8
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3083-77-0
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95058-81-4
519 suppliers
$6.00/100mg
3083-77-0
382 suppliers
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847650-91-3
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3083-77-0
382 suppliers
$6.00/1g