ChemicalBook CAS DataBase List 1-Iodo-2-nitrobenzene

1-Iodo-2-nitrobenzene synthesis

10synthesis methods

Product Name:1-Iodo-2-nitrobenzene
CAS Number:609-73-4
Molecular formula:C6H4INO2
Molecular Weight:249.01

552-16-9
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609-73-4
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Yield:609-73-4 93%

Reaction Conditions:

with 1-iodo-3,5,5-trimethylhydantoin in tetrachloromethane for 24 h;Reflux;Irradiation;Concentration;Time;Solvent;Reagent/catalyst;

Steps:

10 EXAMPLE 10 Iododecarboxylation of arylcarboxylic acids
EXAMPLE 10 Iododecarboxylation of arylcarboxylic acids [00234] A mixture of ArC0₂H (1 mmol), N-iodoamide, and solvent (5 mL) was refluxed (A) under irradiation with 250 W tungsten lamp (hv). The cold reaction mixture was washed with 1 M aq Na₂S0₃ (2 x 5 mL), dried over Na₂S0₄, filtered and concentrated in vacuo to obtain crude iodoarene Ar-I. The crude product was purified by chromatography on silica gel (eluent hexane/DCM 100:0 to 0:100). The results are presented in Table 17. [00235] Table 10.1 Iododecarboxylation of arylcarboxylic acids using different iodoamides

References:

TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED;NISNEVICH, Gennady;KULBITSKI, Kseniya;GANDELMAN, Mark WO2015/68159, 2015, A2 Location in patent:Paragraph 00234-00235

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88-74-4 Synthesis