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ChemicalBook CAS DataBase List (1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE

(1-METHYL-1H-BENZIMIDAZOL-2-YL)METHYLAMINE synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine; 1-[(1-(cyano-​2-​ethoxy-​2-​oxoethylidenaminooxy)​dimethylamino-​morpholino)]-uronium hexafluorophosphate / dichloromethane / 2 h / 20 °C
2: acetic acid / 1 h / 70 °C
3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

References:

ANTABIO SAS;LEIRIS, Simon;DAVIES, David Thomas;EVERETT, Martin;SPRYNSKI, Nicolas;SUTTON, Jonathan Mark;BODNARCHUK, Michael Steven;PALLIN, Thomas David;CRIDLAND, Andrew Peter;BLENCH, Toby Jonathan;CLARK, David Edward;ELLIOTT, Richard Leonard WO2018/172423, 2018, A1