1-METHYL-3-TRIFLUOROMETHYL-2-PYRAZOLIN-5-ONE synthesis
2synthesis methods
- Product Name:1-METHYL-3-TRIFLUOROMETHYL-2-PYRAZOLIN-5-ONE
- CAS Number:1481-02-3
- Molecular formula:C5H5F3N2O
- Molecular Weight:166.1
Yield: 85.8%
Reaction Conditions:
in ethanol at 50; for 5 h;
Steps:
1.1 (1) Preparation of 1-methyl-3-trifluoromethyl-5-pyrazolone intermediate:
0.1 ml of methyl hydrazine and 250 mL three-necked flask, add 10 mL of anhydrous ethanol, stirring heated to 50 C , dropwise 0. 1moL ethyl trifluoroacetoacetate, heating reflux 5 h, cooling crystallization , Vacuum filtration, drying, in a yellow solid; Yield: 85.8%.
References:
Guizhou University;XUE, WEI;GONG, HUA YU;WANG, ZHONG BO;ZHANG, JIAN;LIU, MIN;ZHU, XUE SONG;XIA, LI JUAN;ZHAO, HONG JU;CHEN, YU CN103951663, 2016, B Location in patent:Paragraph 0091; 0092; 0093
