1-(Trimethylsilyl)-4-nitrobenzene synthesis

10synthesis methods

Product Name:1-(Trimethylsilyl)-4-nitrobenzene
CAS Number:4405-33-8
Molecular formula:C9H13NO2Si
Molecular Weight:195.29

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27607-77-8 Synthesis

Trimethylsilyl trifluoromethanesulfonate

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4405-33-8
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$106.00/50mg

Yield:4405-33-8 80 %Chromat.

Reaction Conditions:

Stage #1: p-nitrobenzene iodidewith phenyllithium in tetrahydrofuran;diethyl ether;cyclohexane at -28; for 2.77778E-06 h;Microflow reactor;
Stage #2: trimethylsilyl trifluoromethanesulfonate in tetrahydrofuran;diethyl ether;cyclohexane at -28; for 0.00255556 h;Microflow reactor;

References:

Nagaki, Aiichiro;Kim, Heejin;Yoshida, Jun-ichi [Angewandte Chemie - International Edition,2009,vol. 48,# 43,p. 8063 - 8065] Location in patent:supporting information; experimental part