1-Phenyl-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione synthesis

7synthesis methods

Product Name:1-Phenyl-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS Number:1015-64-1
Molecular formula:C11H10N2O2
Molecular Weight:202.21

62-53-3 Synthesis

62-53-3
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5-acetyl-4-hydroxy-2H-1,3-Thiazine-2,6(3H)-dione

91114-97-5
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1-Phenyl-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

1015-64-1
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Yield:1015-64-1 40.7%

Reaction Conditions:

in N,N-dimethyl-formamide;Reflux;

Steps:

19-2 6-methyl-1-phenylpyrimidine-2,4(1H,3H)-dione

To a solution of 19b (20 g, 106 mmol) in DMF (15 mL) was added aniline (9.2 mL) at r.t., the reaction was stirred at reflux until 20b disappeared by TLC. The mixture was concentrated, the residue was washed with EtOH, and filtered to give 19c as a yellow solid (880 mg, yield: 40.7%). MS (m/z): 203.1 (M+1)⁺.

References:

WO2014/15523,2014,A1 Location in patent:Page/Page column 103; 104