1,3-Dimethyl-8-(pyridin-4-yl)-1H-purine-2,6(3H,7H)-dione synthesis
- Product Name:1,3-Dimethyl-8-(pyridin-4-yl)-1H-purine-2,6(3H,7H)-dione
- CAS Number:1088-64-8
- Molecular formula:C12H11N5O2
- Molecular Weight:257.25
Yield:1088-64-8 47 %
Reaction Conditions:
with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in water;acetonitrile at 30;
Steps:
2 Procedure A:
General procedure: 5,6-diamino-1,3-dimethyluracil (213.0 mg, 1.25 mmol, 1 equiv), arylbenzaldehyde (1.25 mmol, 1 equiv), azobisisobutyronitrile (AIBN, 4.1 mg, 0.025 mmol, 0.02 equiv), and n-bromosuccinimide (NBS, 155.7 mg, 0.875 mmol, 0.7 equiv) were added to a solution of MeCN/H2O (9:1, 5 mL). The reaction mixture was stirred at 30oC for 3 hours. The resulting precipitate was filtered and rinsed with ethanol to afford the desired product.
References:
WO2023/23867,2023,A1 Location in patent:Paragraph 00291-00292; 00295; 00341