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1,3-Dimethyl-8-(pyridin-4-yl)-1H-purine-2,6(3H,7H)-dione synthesis

1synthesis methods
-

Yield:1088-64-8 47 %

Reaction Conditions:

with N-Bromosuccinimide;2,2'-azobis(isobutyronitrile) in water;acetonitrile at 30;

Steps:

2 Procedure A:

General procedure: 5,6-diamino-1,3-dimethyluracil (213.0 mg, 1.25 mmol, 1 equiv), arylbenzaldehyde (1.25 mmol, 1 equiv), azobisisobutyronitrile (AIBN, 4.1 mg, 0.025 mmol, 0.02 equiv), and n-bromosuccinimide (NBS, 155.7 mg, 0.875 mmol, 0.7 equiv) were added to a solution of MeCN/H2O (9:1, 5 mL). The reaction mixture was stirred at 30oC for 3 hours. The resulting precipitate was filtered and rinsed with ethanol to afford the desired product.

References:

WO2023/23867,2023,A1 Location in patent:Paragraph 00291-00292; 00295; 00341