ChemicalBook CAS DataBase List 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID synthesis

10synthesis methods

Product Name:1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
CAS Number:113100-53-1
Molecular formula:C6H5F3N2O2
Molecular Weight:194.11

1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile

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1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

113100-53-1
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$7.00/100mg

Yield:113100-53-1 > 99 %Chromat.

Reaction Conditions:

with water;sodium hydroxide in methanol at 75; for 4 h;Product distribution / selectivity;

Steps:

7

0.50 g of Compound (III) having purity of 98.1% by weight was dissolved in 4 ml of methanol, followed by further adding 2.0 g of a 32% by weight aqueous solution of sodium hydroxide, further followed by reacting at an external temperature of 75°C for 4 hours. The reaction solution was observed by HPLC after cooling, and the result showed that the reaction yield of Compound (V) was 99% or more.

References:

EP2128139,2009,A1 Location in patent:Page/Page column 25