ChemicalBook CAS DataBase List 2-(Di-t-butylphosphino)-3-methoxy-6-methyl-2',4',6'-tri-i-propyl-1,1'-biphenyl

2-(Di-t-butylphosphino)-3-methoxy-6-methyl-2',4',6'-tri-i-propyl-1,1'-biphenyl synthesis

6synthesis methods

Product Name:2-(Di-t-butylphosphino)-3-methoxy-6-methyl-2',4',6'-tri-i-propyl-1,1'-biphenyl
CAS Number:1262046-34-3
Molecular formula:C31H49OP
Molecular Weight:468.69

21524-34-5 Synthesis

21524-34-5
264 suppliers
$6.00/5g

2-(Di-t-butylphosphino)-3-methoxy-6-methyl-2',4',6'-tri-i-propyl-1,1'-biphenyl

1262046-34-3
85 suppliers
$66.00/50mg

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: magnesium; ethylene dibromide / tetrahydrofuran / 1 h / Inert atmosphere; Reflux
2.1: n-butyllithium / tetrahydrofuran; hexane / 3 h / -78 °C / Inert atmosphere
2.2: -78 - 20 °C / Inert atmosphere
2.3: 1.5 h / 0 - 20 °C / Inert atmosphere
3.1: tert.-butyl lithium / toluene; pentane / 0.67 h / -78 °C / Inert atmosphere
3.2: 20 h / -78 - 140 °C / Inert atmosphere

References:

Wu, Xiaoxing;Fors, Brett P.;Buchwald, Stephen L. [Angewandte Chemie - International Edition,2011,vol. 50,# 42,p. 9943 - 9947]

FullText

13716-10-4 Synthesis