ChemicalBook CAS DataBase List 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)CHLOROBENZENE

4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)CHLOROBENZENE synthesis

11synthesis methods

Product Name:4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)CHLOROBENZENE
CAS Number:195062-61-4
Molecular formula:C12H16BClO2
Molecular Weight:238.52

76-09-5 Synthesis

76-09-5
373 suppliers
$8.19/250mg

1679-18-1 Synthesis

1679-18-1
586 suppliers
$10.00/1g

4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)CHLOROBENZENE

195062-61-4
134 suppliers
$8.00/1g

Yield: 92%

Reaction Conditions:

with magnesium sulfate in diethyl ether at 20; for 16 h;Inert atmosphere;Schlenk technique;

Steps:

Synthesis of Pinacol Boronic Esters from Boronic Acids; General Procedure (GP1)
General procedure: A mixture of boronic acid (1.0 equiv), pinacol (1.0 equiv) and anhydrous MgSO4 (4.0 equiv) in Et2O (0.5 M) was stirred at r.t. for 16 h. The reaction mixture was filtered and the solvent removed in vacuo. The crude material was purified by distillation or flash column chromatography to give the pure boronic ester.

References:

Casoni, Giorgia;Myers, Eddie L.;Aggarwal, Varinder K. [Synthesis,2016,vol. 48,# 19,art. no. SS-2016-C0356-OP,p. 3241 - 3253]