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1H-TETRAZOLE-1-ACETYL CHLORIDE synthesis

2synthesis methods
-

Yield:41223-92-1 58%

Reaction Conditions:

in benzene;

Steps:

40 7β-[1-(1H)-Tetrazolylacetamido]-3-methyl-Δ3 -0-2-isocephem-4-carboxylic acid STR247

EXAMPLE 40 7β-[1-(1H)-Tetrazolylacetamido]-3-methyl-Δ3 -0-2-isocephem-4-carboxylic acid STR247 1-(1H)-Tetrazolylacetic acid (256 mg.), 6.25 ml. of benzene and 1.25 ml. oxalyl chloride was stirred at 24° for 3 days. The starting acid was filtered off and evaporation of the solution gave 1-(1H)-tetrazoleacetyl chloride in 58% yield.

References:

US4012383,1977,A

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