ChemicalBook CAS DataBase List 2-(3-AMINOPHENYL)PYRIDINE

2-(3-AMINOPHENYL)PYRIDINE synthesis

9synthesis methods

Product Name:2-(3-AMINOPHENYL)PYRIDINE
CAS Number:15889-32-4
Molecular formula:C11H10N2
Molecular Weight:170.21

109-09-1
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$10.60/1gm:

13331-27-6 Synthesis

13331-27-6
352 suppliers
$5.00/1g

15889-32-4
74 suppliers
$65.00/100mg

Yield: 78%

Reaction Conditions:

with potassium carbonate;hydrazine hydrate in water;N,N-dimethyl-formamide at 80; for 9 h;Suzuki-Miyaura Coupling;

Steps:

2.4 Preparation of Aminobiphenyls in the Presenceof Ni7-Pd3(at)BIHPS
General procedure: Aryl halide (1.0 mmol), phenylboronic acid (1.1 mmol),K2CO3(2.0 mmol), Ni7-Pd3BIHPS (0.03 g) and H2O/DMF (2:1, 3 mL) were mixed and heated at 80 °C for anappropriate time (monitored by TLC). Then, hydrazinehydrate (80 wt%, 6 eq) was added to the reaction vessel.After completion of the reduction process, the mixturewas filtered and washed with water. The organic layer wasextracted with ethyl acetate (3 × 15 mL) and dried overMgSO4.Then the organic solution was concentrated andpurified by column chromatography to obtain the finalproduct.

References:

Beigbaghlou, Somayyeh Sarvi;Javad Kalbasi, Roozbeh;Marjani, Katayoun;Habibi, Azizollah [Catalysis Letters,2018,vol. 148,# 8,p. 2446 - 2458]

109-04-6 Synthesis