2,4-Dimethylthiazole-5-carboxylic acid synthesis
- Product Name:2,4-Dimethylthiazole-5-carboxylic acid
- CAS Number:53137-27-2
- Molecular formula:C6H7NO2S
- Molecular Weight:157.19
7210-77-7
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$11.00/100mg
53137-27-2
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$8.00/1g
Yield: 90%
Reaction Conditions:
with sodium hydroxide in ethanol;water for 4 h;Reflux;
Steps:
3.1.3. Procedure for the synthesis of 4-methyl 2-substitutedthiazole-5-carboxylic acid (1d, 3d)
General procedure: The appropriate ethyl ester (1c, 3c) (5.8 mmol) was refluxed for4 h in a mixture of equal volumes of aqueous 10% NaOH (20 mL) andEthanol (20 mL). After completion of the reaction, ethanol wasevaporated under reduced pressure and the remaining solutionwasthen extracted with ethyl acetate. The organic layer was discardedwhile the aqueous layer was acidified to pH 3 with aqueous 10%hydrochloric acid. The mixturewas then evaporated under reducedpressure and the solid obtained was then dissolved in methanolwhile the remaining insoluble NaCl was discarded. Evaporating themethanol afforded the desired pure acids 1d and 3d.
References:
Ghonim, Aya E.;Ligresti, Alessia;Rabbito, Alessandro;Mahmoud, Ali Mokhtar;Di Marzo, Vincenzo;Osman, Noha A.;Abadi, Ashraf H. [European Journal of Medicinal Chemistry,2019,vol. 180,p. 154 - 170]
28599-52-2
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$27.57/250mgs:
53137-27-2
165 suppliers
$8.00/1g
7210-77-7
141 suppliers
$11.00/100mg
53137-27-2
165 suppliers
$8.00/1g
66806-33-5
15 suppliers
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