ChemicalBook CAS DataBase List 2-Amino-5-bromothiazole

2-Amino-5-bromothiazole synthesis

5synthesis methods

Product Name:2-Amino-5-bromothiazole
CAS Number:3034-22-8
Molecular formula:C3H3BrN2S
Molecular Weight:179.04

96-50-4 Synthesis

96-50-4
511 suppliers
$5.00/5g

3034-22-8
208 suppliers
$7.00/250mg

Yield:3034-22-8 75%

Reaction Conditions:

with bromine;acetic acid at 0 - 30; for 2 h;

Steps:

5.a
(a)at 0 ° C2-Aminothiazole (400 mg, 4 mmol) was dissolved in 16 mLAcetic acid solution,Bromine (408 μL, 8 mmol) was slowly added dropwise.The mixture was further stirred at room temperature for 2 hours,TLC reaction was monitored until the reaction was completed,The pH was adjusted to 7-8 with saturated NaHCO3,Ethyl acetate (20 mL x 3), washed with saturated saline and the organic layer was mixed,Dry over anhydrous sodium sulfate, filter and concentrate and purify by column chromatography5-Bromothiazol-2-amine(520 mg, 75% yield).

References:

Chinese Academy Of Sciences Shanghai Organic Chemistry Institute;Zhu Jidong;Gu Shoulai;Si Xiaojia;Xie Jingjing;Shen Jian CN107286150, 2017, A Location in patent:Paragraph 0354; 0355; 0356

FullText