2-(AMINOCARBONYL)NICOTINIC ACID synthesis
- Product Name:2-(AMINOCARBONYL)NICOTINIC ACID
- CAS Number:5860-70-8
- Molecular formula:C7H6N2O3
- Molecular Weight:166.13
699-98-9
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5860-70-8
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Yield:5860-70-8 81.9%
Reaction Conditions:
with ammonium hydroxide in water; for 2.5 h;Cooling with ice;
Steps:
1.B Step B: Preparation of 2-carbamoylpyridine-3-carboxylic acid
Place 13.6g (200mmol) of 25% ammonia water in a 100mL eggplant-shaped flask, slowly add 7.46g (50mmol) of 2,3-pyridinedicarboxylic anhydride under ice-water bath conditions, stir for 2.5h, heat up to 40°C, and continue The reaction was carried out for 3.5h, vacuumed after cooling, and the pH value was adjusted to about 5 with concentrated hydrochloric acid, and a large amount of white solid was precipitated, which was filtered and dried to obtain 6.8g of 2-carbamoylpyridine-3-carboxylic acid white solid, the yield was 81.9%.
References:
CN113979936,2022,A Location in patent:Paragraph 0036; 0040-0041
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5860-70-8
47 suppliers
$60.00/100mg