ChemicalBook CAS DataBase List 2-Chlorophenylacetic acid

2-Chlorophenylacetic acid synthesis

11synthesis methods

Product Name:2-Chlorophenylacetic acid
CAS Number:2444-36-2
Molecular formula:C8H7ClO2
Molecular Weight:170.59

611-19-8 Synthesis

611-19-8
422 suppliers
$7.00/25g

71-36-3 Synthesis

71-36-3
1019 suppliers
$14.00/25mL

2444-36-2
441 suppliers
$5.00/25g

Yield:2444-36-2 93.7%

Reaction Conditions:

Stage #1:butan-1-ol with cobalt(II) acetate;cobalt(II) nitrate at 40; under 3750.38 Torr; for 2 h;Autoclave;
Stage #2:1-chloro-2-(chloromethyl)benzene with sodium hydroxide in water at 40; under 2250.23 Torr; for 12 h;Autoclave;Concentration;Pressure;Temperature;

Steps:

7 Synthesis of O-chlorophenylacetic acid
To a 3000 L autoclaveAdding 1,200 kg of n-butanolAnd cobalt nitrate 0.2,Cobalt acetate 1.5kg, CO replacement after adjusting the pressure of 0.5MPa, The temperature was raised to 40 ° C for 2 hours.Pressure relief by adding sodium hydroxide 200kg and water 800kg,Through the CO adjustment pressure of 0.3MPa,Heating up to 40° C ,Slowly and slowly adding o-chlorobenzyl chloride 300kg,After the addition reaction was incubated for 12 hours.Cooling pressure after standing static stratification,Organic phase with water 400kg × 2 wash,Also said that the water twice cleaning,Collecting water,concentrate,With concentrated hydrochloric acid to adjust the PH 3,Cooling and drying products,The yield was 93.7%Purity of 99.6%.

References:

Shanghai Yinsheng Biological Technology Co., Ltd.;Gu Huan;Xu Zhenhua;Zhang Zongyin;Li Xianyue;Xu Lili;Shi Zhen;Li Jianli CN106496013, 2017, A Location in patent:Paragraph 0056-0059; 0060-0063; 0064-0067; 0068-0071

FullText

201230-82-2 Synthesis