ChemicalBook CAS DataBase List 2-COUMARANONE

2-COUMARANONE synthesis

12synthesis methods

Product Name:2-COUMARANONE
CAS Number:553-86-6
Molecular formula:C8H6O2
Molecular Weight:134.13

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553-86-6
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$40.74/1g

Yield:553-86-6 98%

Reaction Conditions:

with sulfuric acid in lithium hydroxide monohydrate;toluene at 100; for 6 h;Reagent/catalyst;Temperature;

Steps:

1.4; 2.4; 3.4

(4) Add 15.2g (100mmol) of o-hydroxyphenylacetic acid and 100mL of toluene to a 250mL three-necked flask, install a water separator, turn on the stirrer and heat the three-necked flask. When heated to 100 °C , add 1mL with a concentration of 8mol/ After the addition of dilute sulfuric acid L, the mixture was heated to reflux for 6h and then ended. After the reaction solution was cooled to room temperature, the filtrate was washed with sodium bisulfite and water in sequence, dried over anhydrous magnesium sulfate, and toluene was distilled off to obtain benzene. With furanone, the yield is 98%.

References:

CN111170973,2020,A Location in patent:Page/Page column 8-10