2-Methylbenzo[g]quinazolin-4(3H)-one synthesis

6synthesis methods

Product Name:2-Methylbenzo[g]quinazolin-4(3H)-one
CAS Number:16673-88-4
Molecular formula:C13H10N2O
Molecular Weight:210.23

108-24-7
5 suppliers
$14.00/250ML

5959-52-4 Synthesis

5959-52-4
206 suppliers
$44.31/1g

16673-88-4
10 suppliers
inquiry

Yield:16673-88-4 72%

Reaction Conditions:

Stage #1: acetic anhydride;2-Amino-3-naphthoic acid for 4 h;Reflux;
Stage #2: with ammonium hydroxide at 100; for 12 h;

Steps:

2 General Method A:

General procedure: 2-Amino-3-naphthoic acid or 2-amino-3-benzoic acid (1 eq) was dissolved in acetic anhydride (0.2 M final) and heated to reflux. After stirring a reflux for 4 h, reaction mixture was cooled to room temperature and solvent was removed by rotary evaporator. Concentrated NH₄OH (0.2 M final) was added to residue and the solution was heated at 100 °C for 12 h. Once cooled to room temperature, the resulting precipitate was collected by filtration and washed with H₂0 and methanol yielding a solid (1.72 g, 72%). 'H and ¹³C NMR were consistent with previous reports.

References:

WO2019/177975,2019,A1 Location in patent:Page/Page column 83; 84-85