ChemicalBook CAS DataBase List 2-(METHYLTHIO) BENZALDEHYDE

2-(METHYLTHIO) BENZALDEHYDE synthesis

12synthesis methods

Product Name:2-(METHYLTHIO) BENZALDEHYDE
CAS Number:7022-45-9
Molecular formula:C8H8OS
Molecular Weight:152.21

67-68-5 Synthesis

67-68-5
1203 suppliers
$15.00/100g

6630-33-7
406 suppliers
$9.00/10g

7022-45-9
134 suppliers
$22.00/250mg

Yield: 93%

Reaction Conditions:

with 1,4-diaza-bicyclo[2.2.2]octane;copper(l) iodide at 130; for 12 h;Sealed tube;Inert atmosphere;

Steps:

2. General procedurefor the methylthiolation reaction:
General procedure: An oven dried pressure tube was chargedwith aryl bromide (1 mmol), CuI (1 mmol), DABCO (2 mmol) and dry DMSO (5 mL).Then the tube was sealed with a teflon cap and heated with stirring at 130 Cin N₂ atmosphere for 12 - 36 h. The completions of reactions weremonitored by TLC. The reaction mixture was then cooled to room temperature. Themass was passed through celite bed, packed in a sinter funnel. Then thefiltered reaction mixture was extracted with ethyl acetate (3 X 20) washed withwater (3 X 20) and brine solution (3 X 10). Ethyl acetate part were collectedand dried over Na₂SO₄, and then evaporated under reducedpressure. The crude products were purified by column chromatography on silicagel to obtain pure product.

References:

Ghosh, Ketaki;Ranjit, Sadananda;Mal, Dipakranjan [Tetrahedron Letters,2015,vol. 56,# 37,p. 5199 - 5202] Location in patent:supporting information

446-52-6 Synthesis