2-(OCTADECYLOXY)ETHANOL synthesis
- Product Name:2-(OCTADECYLOXY)ETHANOL
- CAS Number:2136-72-3
- Molecular formula:C20H42O2
- Molecular Weight:314.55
107-21-1
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112-89-0
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2136-72-3
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Yield:2136-72-3 52.5%
Reaction Conditions:
Stage #1: ethylene glycolwith sodium hydride in N,N-dimethyl-formamide at 0 - 5;Inert atmosphere;
Stage #2: 1-Bromooctadecanewith potassium iodide in N,N-dimethyl-formamide at 90 - 95; for 4 h;
Steps:
6.1 (1) 2-(octadecyloxy)ethan-1-ol
Under the protection of N2, NaH (9.0 g, 225 mmol) was added to ethylene glycol (41.9 g, 675 mmol) in anhydrous DMF (250 mL) in portions at 0-5 °C. Add KI (24.9 g, 150 mmol) (exothermic) and octadecyl bromide (50.0 g, 150 mmol), heat up to 90-95 °C for 4 hrs, TLC detects the remaining octadecyl bromide, cool to about 30 °C was poured into ice water (1 L), extracted once with ethyl acetate (EA, 500 mL), the organic phase was washed with H2O (250 mL) and saturated NaCl (400 mL) in turn, concentrated to dryness, purified by column, and concentrated. Add acetonitrile (CAN, 160 mL) dryly to crystallize at room temperature, filter, collect the filter cake, and dry at room temperature to obtain 21.6 g of white powdery solid, yield: 52.5%.
References:
CN113817009,2021,A Location in patent:Paragraph 0111-0112
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2136-72-3
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107-21-1
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2136-72-3
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112-92-5
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2136-72-3
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107-21-1
1302 suppliers
$10.00/25g
2136-72-3
51 suppliers
$22.00/500mg