2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL synthesis
- Product Name:2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL
- CAS Number:5424-47-5
- Molecular formula:C9H14ClNOS
- Molecular Weight:219.73
88-15-3
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50-00-0
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506-59-2
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5424-47-5
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$9.00/5g
Yield: 94%
Reaction Conditions:
with hydrogenchloride in water;isopropyl alcohol for 6 h;Reflux;
Steps:
3.1 3-(dimethylamino)-1-(2-thienyl)-1-propanone hydrochloride 2a:
Following a protocol defined by Robertson [1], a mixture of 2-acetylthiophene (128g, 1000 mmol), dimethylamine hydrochloride (90 g,1100 mmol), paraformaldehyde (41 g, 1400 mmol), concentrated hydrochloric acid(5 mL) and isopropanol (500 mL) was refluxed for 6 h. After the completion ofthe reaction, the obtained solution was cooled to 0 oC and stirredfor 1 h more. The slurry was then filtered, and the solid was washed with coldisopropanol, dried for 16 h at 50 oC to afford 2a.
References:
Chen, Xiang;Liu, Zhi-Qiang;Lin, Chao-Ping;Zheng, Yu-Guo [Bioorganic Chemistry,2016,vol. 65,p. 82 - 89] Location in patent:supporting information
