2-(trifluoromethyl)-1,4-Benzenedicarboxylic acid synthesis

6synthesis methods

Product Name:2-(trifluoromethyl)-1,4-Benzenedicarboxylic acid
CAS Number:1483-47-2
Molecular formula:C9H5F3O4
Molecular Weight:234.13

553-94-6
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2-(trifluoromethyl)-1,4-Benzenedicarboxylic acid

1483-47-2
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Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: magnesium / tetrahydrofuran / Inert atmosphere; Reflux
1.2: -78 - 20 °C / Inert atmosphere
1.3: Reflux
2.1: copper(l) chloride; tert.-butylhydroperoxide / dichloromethane; methanol; water / 12 h / 0 - 20 °C
3.1: nitric acid / water / 24 h / 180 °C

References:

Horcajada, Patricia;Chevreau, Hubert;Heurtaux, Daniela;Benyettou, Farah;Salles, Fabrice;Devic, Thomas;Garcia-Marquez, Alfonso;Yu, Cihang;Lavrard, Hubert;Dutson, Claire L.;Magnier, Emmanuel;Maurin, Guillaume;Elkaïm, Erik;Serre, Christian [Chemical Communications,2014,vol. 50,# 52,p. 6872 - 6874]

84796-70-3
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1483-47-2
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References

4-METHYL-2-(TRIFLUOROMETHYL)BENZOIC ACID

120985-64-0
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$29.00/100mg

1483-47-2
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References

586-35-6
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77152-08-0
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1483-47-2
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References

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

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1483-47-2
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References