ChemicalBook CAS DataBase List 2-(TRIFLUOROMETHYL)BENZYLAMINE

2-(TRIFLUOROMETHYL)BENZYLAMINE synthesis

7synthesis methods

Product Name:2-(TRIFLUOROMETHYL)BENZYLAMINE
CAS Number:3048-01-9
Molecular formula:C8H8F3N
Molecular Weight:175.15

Benzene, 1-(azidomethyl)-2-(trifluoromethyl)-

823189-03-3
0 suppliers
inquiry

3048-01-9
165 suppliers
$6.00/1g

Yield:-

Reaction Conditions:

Stage #1: 1-(azidomethyl)-2-(trifluoromethyl)benzenewith hydrogenchloride;tin(ll) chloride in water at 80; for 2 h;
Stage #2: with sodium hydrogencarbonate in water;

Steps:

4.2

Step 2 -Preparation of 1-[2-(trifluoromethyl)phenyl]methanamine To a solution of step-1 intermediate (0.200 g, 0.993 mmol) in conc. HCl tin (II)chloride (0.673 g, 2.98 mmol) was added. The reaction mixture was stirred at 80° C. for 2 h. The reaction mixture quenched in water, neutralized with sodium bicarbonate and extracted with mixture of (1-1.5%) methanol: DCM. The organic layer was separated, dried over anhydrous sodium sulphate and concentrated to afford 0.150 g of the desired product. ¹HNMR (DMSO-d₆): δ 7.43 (d, J=7.2 Hz, 2H), 7.64-7.66 (m, 3H), 7.78 (m, 1H).

References:

US2012/108583,2012,A1 Location in patent:Page/Page column 23

447-60-9 Synthesis