3,5-Bis(trifluoromethyl)phenylacetonitrile synthesis
- Product Name:3,5-Bis(trifluoromethyl)phenylacetonitrile
- CAS Number:85068-32-2
- Molecular formula:C10H5F6N
- Molecular Weight:253.14
328-72-3
85 suppliers
$11.00/100mg
372-09-8
350 suppliers
$20.00/25g
85068-32-2
151 suppliers
$10.00/1g
Yield:-
Reaction Conditions:
with dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane;bis(η3-allyl-μ-chloropalladium(II)) in 1,3,5-trimethyl-benzene at 0 - 145; for 20.25 h;Inert atmosphere;Large scale;Solvent;
Steps:
1.2 2,2- (3,5-bis-trifluoromethylphenyl) acetonitrile was prepared:
50L clean glass vessel, dried in a stream of nitrogen was added 20kg mesitylene, open stirring, degassed with nitrogen purge 15min, was added under stirring 5.0kg3,5- bis-trifluoromethyl-chlorobenzene (20.1mol), 2.5kg cyano acetate (21.0mol), 8.0g of allyl palladium chloride dimer (0.0217mol, 0.22mol%), 27g2- dicyclohexyl phosphino-2 ', 6'-dimethoxy biphenyl (0.066mol , 0.66mol%); under nitrogen flow, the temperature of the reaction system was gradually raised to 145 20h the reaction, the reaction system was then lowered to room temperature, the reaction was filtered to remove sodium chloride, and the filtrate recovery spin dry mesitylene, and concentrated to give 5.5kg the residue is 2- (3,5-bis-trifluoromethylphenyl) acetonitrile crude product, detecting the GC purity was 92%, a yield of 81%.
References:
Hefei Leaf Biotechnology Limited;Deng, Jin;Fu, Yao;Wang, Peng;Ding, Fan;Xu, Qiang;Yu, Sanxi;Ding, Feijiao;Wujiang, Jiang CN105541593, 2016, A Location in patent:Paragraph 0040; 0041
328-70-1
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1071-36-9
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$6.00/1g
85068-32-2
151 suppliers
$10.00/1g