3-AMINO-2,4,5-TRIFLUOROBENZOIC ACID synthesis
- Product Name:3-AMINO-2,4,5-TRIFLUOROBENZOIC ACID
- CAS Number:119385-80-7
- Molecular formula:C7H4F3NO2
- Molecular Weight:191.11
25693-94-1
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Yield: 76%
Reaction Conditions:
with hydrogenchloride;water at 100;
Steps:
1-5
0.04 mol of compound of formula (1) is added at room temperature,Add 200 g of concentrated hydrochloric acid, heat up to 100 ° C and keep the raw materials disappear. After the reaction, reduce the reaction solution to about 0 ° C, adjust the pH to 1 ~ 2 with 30% liquid alkali, stir for 1 hour, filter out the solids, and filter the filtrate through 450g. It was extracted with ethyl acetate, and the organic layer was concentrated to a remaining volume of 50 ml. The precipitated solid was collected by filtration and dried to obtain 5.8 g of a compound of formula (2) with a yield of 76%.
References:
Chongqing Jingzhi Pharmaceutical Technology Development Co., Ltd.;Li Qian;Deng Wei;Zhou Lingfeng;Ren Li;Yu Mengjun CN110577469, 2019, A Location in patent:Paragraph 5; 6
169542-84-1
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119385-80-7
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1835-65-0
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119385-80-7
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