ChemicalBook CAS DataBase List 3-Bromo-2-hydroxypyridine

3-Bromo-2-hydroxypyridine synthesis

4synthesis methods

Product Name:3-Bromo-2-hydroxypyridine
CAS Number:13466-43-8
Molecular formula:C5H4BrNO
Molecular Weight:174

142-08-5 Synthesis

142-08-5
494 suppliers
$6.00/5g

13466-43-8
249 suppliers
$6.00/1g

Yield:13466-43-8 78%

Reaction Conditions:

with bromine;potassium bromide in water at 20; for 24.25 h;

Steps:

1.V.T77-1 Step T77-1.
3-l3romo-pyridin-2-ol. A stirred suspension of 2-pyridone (77-0, 19 g, 200 mmol) in 200 mE of 1 M aqueous K13r at room temperature was treated over 15 mm with bromine (32 g, 200 mmol; CAUTION: Large quantities of 13r2 should be handled careffilly) in 200 mE of 1 M aqueous K13r, then stirred vigorously at room temperature 0/N. After 24 h, this solution deposited crystals which were filtered off and then recrystallized from acetonitrile to give 27.2 g (78%) of 3-bromo- pyridin-2-ol. (77-1) [J. Am. Chem. Soc. 1982, 104, 4142- 4146; Bioorg. Med. Chem. Lett. 2002, 12, 197-200; JMed Chem. 1979, 22, 1284-1290.] Molecular weight calcd. for C5H4I3rNO: 173; (M+H) found: 174

References:

Ocera Therapeutics, Inc.;Hoveyda, Hamid R.;Fraser, Graeme L.;Peterson, Mark US2018/110824, 2018, A1 Location in patent:Paragraph 0497; 0498; 0499

FullText

13534-99-1 Synthesis