ChemicalBook CAS DataBase List 3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER

3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER synthesis

10synthesis methods

Product Name:3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER
CAS Number:99548-54-6
Molecular formula:C9H9BrO2
Molecular Weight:229.07

67-56-1 Synthesis

67-56-1
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76006-33-2 Synthesis

76006-33-2
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$10.00/5g

3-BROMO-2-METHYL-BENZOIC ACID METHYL ESTER

99548-54-6
157 suppliers
$5.00/1g

Yield:99548-54-6 99%

Reaction Conditions:

with thionyl chloride at 70; for 1.5 h;

Steps:

112.1
To a mixture of 3-bromo-2-methylbenzoic acid (5.0 g, 23 mmol) in MeOH (80 mL) was added 50C12 (11.0 g, 93 mmol) at 20°C. The mixture was stirred for 1.5h at 70°C. Thevolatiles were removed and the residue was taken up by EtOAc (100 mL), which was washed sequentially with saturated NaHCO3 and brine (each 100 mL). The EtOAc layer was dried over Na2504, concentrated and the residue was purified by flash column chromatography to give methyl 3-bromo-2-methylbenzoate (5.3g, 99% yield) as a red solid.

References:

RQX PHARMACEUTICALS, INC.;GENENTECH, INC.;CHEN, Yongsheng;SMITH, Peter Andrew;ROBERTS, Tucker Curran;HIGUCHI, Robert I.;PARASELLI, Prasuna;KOEHLER, Michael F. T.;SCHWARZ, Jacob Bradley;CRAWFORD, James John;LY, Cuong Q.;HANAN, Emily J.;HU, Huiyong;YU, Zhiyong WO2017/84630, 2017, A1 Location in patent:Paragraph 00545

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76006-33-2 Synthesis

76006-33-2
317 suppliers
$10.00/5g