ChemicalBook CAS DataBase List (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE

(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE synthesis

7synthesis methods

Product Name:(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE
CAS Number:89031-84-5
Molecular formula:C9H21BrOSi
Molecular Weight:253.25

(3-Bromopropoxy)-tert-butyldimethylsilane is a reagent for the preparation of piperidoyl carbonyl sulfonate, as a new type of anti-hyperlipidemia drug, through the adaptor protein autosomal recessive high Cholesterolemia upregulates the ldl receptor. The mixtrue of 3-Bromopropanol , imidazole and TBDMS was stirred at overnight and purified to give (3-Bromopropoxy)-tert-butyldimethylsilane.

29681-57-0
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627-18-9
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(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE

89031-84-5
213 suppliers
$10.00/1g

Yield:89031-84-5 92%

Reaction Conditions:

with 1H-imidazole in dichloromethane at 20; for 0.166667 h;Cooling with ice;

Steps:

31.a (3-Bromopropoxy) (tert-butyl) dimethylsilane
3-Bromopropanol (4.14 g, 30 mmol),Was added to DCM (50 mL), imidazole (2.5 g, 30 mmol) was added, stirred under ice for 10 min, TBDMS (4.5 g, 30 mmol) was added and the reaction was continued at room temperature. The next day, DCM (50 mL) (30 mL X3), dried over anhydrous magnesium sulfate and concentrated to give 7 g of a colorless oil in 92% yield

References:

Chinese Academy Of Medical Sciences Pharmaceutical Institute;Xu Boling;Chen Xiaoguang;Zhou Jie;Ji Ming;Yao Haiping;Zhou Qin CN107098886, 2017, A Location in patent:Paragraph 0501; 0502

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18162-48-6 Synthesis