ChemicalBook CAS DataBase List 3-Buten-1-ol

3-Buten-1-ol synthesis

15synthesis methods

Product Name:3-Buten-1-ol
CAS Number:627-27-0
Molecular formula:C4H8O
Molecular Weight:72.11

The synthesis of 3-Buten-1-ol is as follows:After adding 24.3 g (1 mol) of magnesium turnings, 50 g of diethyl ether and 1 ml of dibromoethane in a 500 mL four-necked flask,A solution of 62.5 g of vinyl chloride (1 mol) dissolved in 200 g of diethyl ether was added dropwise to magnesium and diethyl ether, and the micro reflux was controlled, and the dropwise addition was completed, and the mixture was kept under a micro reflux for 2 hours, and the temperature was lowered to -5 °C;Then 44 g (1 mol) of ethylene oxide was dissolved in 60 g of diethyl ether. Ethylene oxide is added dropwise to the vinylmagnesium chloride solution prepared above, control the temperature -5-5 degrees, and stir at this temperature for 1 hour. Sampling gas phase analysis until the reaction is complete; pour the reaction solution into a 1000 mL beaker, Add 200mL of ice water and add ammonium chloride until the residual magnesium disappears. Control the temperature 0-10 ° C, stir for 1 hour after the addition, add salt to saturation, static layering. The organic layer was separated and washed twice with 100 ml of saturated brine, and a polymerization inhibitor was added. The product is subjected to rectification to obtain 53 g of 3-buten-1-ol, and the content is 99.2%. The yield was 73.6%.

142860-83-1
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627-27-0
381 suppliers
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Yield:627-27-0 93%

Reaction Conditions:

with t-butyl bromide in acetonitrile; for 1 h;Reflux;chemoselective reaction;

Steps:

Representative procedure for the deprotection of the PMB ethers by t-BuBr

General procedure: To asolution of the PMB ether (1 mmol) in acetonitrile (10 mL), t-BuBr (1.1 equiv)was added and stirred at reflux. After completion of the reaction (monitored byTLC), it was concentrated under reduced pressure and the resulting crude wasdissolved in ethyl acetate (50 mL) and washed with saturated sodiumhydrogenocarbonate (25 mL). The aqueous layer was extracted with ethylacetate (2 5 mL) and the combine organic layer was washed with brinesolution, dried (MgSO4), concentrated under reduced pressure and the residuewas purified by column chromatography (silica gel, EtOAc, cyclohexane) toafford the corresponding alcohol.

References:

Rival, Nicolas;Albornoz Grados, Arantxa;Schiavo, Lucie;Colobert, Fran?oise;Hanquet, Gilles [Tetrahedron Letters,2015,vol. 56,# 49,p. 6823 - 6826]

927-74-2 Synthesis

927-74-2
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627-27-0
381 suppliers
$8.00/1g

References

50-00-0 Synthesis

50-00-0
844 suppliers
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106-95-6 Synthesis

106-95-6
415 suppliers
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627-27-0
381 suppliers
$8.00/1g

References

110-63-4 Synthesis

110-63-4
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109-99-9 Synthesis

109-99-9
1030 suppliers
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627-27-0
381 suppliers
$8.00/1g

References

50-00-0 Synthesis

50-00-0
844 suppliers
$10.00/25g

187737-37-7 Synthesis

187737-37-7
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627-27-0
381 suppliers
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References

3-Buten-1-ol Related Search:

3-SULFOLENE CIS-BUTENEDIOIC ANHYDRIDE Allyl bromide Fumaric acid Methanol Allyl chloride 1-BUTENE Maleic acid 2,4-Diamino-6-hydroxypyrimidine Methyl 4-bromobenzoate