3-Methylanthranilic acid synthesis
- Product Name:3-Methylanthranilic acid
- CAS Number:4389-45-1
- Molecular formula:C8H9NO2
- Molecular Weight:151.16
5437-38-7
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4389-45-1
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Yield:4389-45-1 99%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethanol at 20; under 760.051 Torr;
Steps:
2-Amino-3-methylbenzamide Step 1
Toasolutionof2-nitro-3-methylbenzoicacid(250mg,1.38mmol)inEtOH(2.80mL) was added 10% palladium on charcoal (8% w/w). The reaction mixture wassequentiallyevacuatedandpurgedwithhydrogenthreetimesthenstirredunderhydrogenat approximately atmospheric pressure and room temperature. The reaction wasmonitored by TLC and upon completion the catalyst was filtered off through a pad ofCeliteTM.Thesolventwasremovedinvacuotogive2-amino-3-methylbenzoicacid(206mg,1.36mmol,99%)asapalepinkamorphoussolid,withouttheneedforfurtherpurification;mp169-171°C,lit.170-172°C.
References:
Sutherell, Charlotte L.;Ley, Steven V. [Synthesis,2017,vol. 49,# 1,art. no. SS-2016-Z0435-OP,p. 135 - 144] Location in patent:supporting information
1127-59-9
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4389-45-1
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15068-35-6
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$9.00/5g
4389-45-1
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99-04-7
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4389-45-1
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1132-03-2
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$106.00/250mg
4389-45-1
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