3-Pyridinecarboxylicacid,6-amino-5-methyl-(9CI) synthesis
- Product Name:3-Pyridinecarboxylicacid,6-amino-5-methyl-(9CI)
- CAS Number:167626-78-0
- Molecular formula:C7H8N2O2
- Molecular Weight:152.15
183428-91-3
113 suppliers
inquiry
167626-78-0
16 suppliers
inquiry
Yield:167626-78-0 88%
Reaction Conditions:
with water;sodium hydroxide for 4 h;Reflux;
Steps:
II Step II: 6-Amino-5-methyl-pyridme-3-carboxylic acid
Step II: 6-Amino-5-methyl-pyridme-3-carboxylic acidTo a stirred suspension of 6-amino-5-methyl-pyridine-3-carbonitrile (6.0 g, 45.0 mmol) in water (40 mL) was added sodium hydroxide (5.4 g, 135.2 mmol) and refluxed for 4 h. Reaction mixture was cooled to room temperature and filtered through Buchner funnel. Filtrate was neutralized with 4N HC1. Solid formed was filtered through Buchner funnel and dried under high vacuum to furnish 6.0 g (88%) of titled intermediate as a white solid.? NMR (400 MHz, CDC13): δ 2.05 (s, 3H), 6.53 (s, 2H), 7.66 (s, 1H), 8.37 (d, J = 2.0 Hz, 1H), 12.29 (brs, 1H). MS (ES) m/z 153.0 (M+l).
References:
WO2013/42139,2013,A1 Location in patent:Page/Page column 83
3430-21-5
394 suppliers
$5.00/1g
167626-78-0
16 suppliers
inquiry