ChemicalBook CAS DataBase List 3'-(Trifluoromethyl)acetophenone

3'-(Trifluoromethyl)acetophenone synthesis

10synthesis methods

Product Name:3'-(Trifluoromethyl)acetophenone
CAS Number:349-76-8
Molecular formula:C9H7F3O
Molecular Weight:188.15

98-08-8
276 suppliers
$9.00/1g

64-19-7 Synthesis

64-19-7
1527 suppliers
$10.00/25ML

349-76-8
372 suppliers
$10.00/1g

Yield:349-76-8 96.3%

Reaction Conditions:

with tetrabutylammonium bromide;sodium tertiary butoxide at 65 - 75; under 3750.38 - 4500.45 Torr; for 9 h;Inert atmosphere;Large scale;Green chemistry;Reagent/catalyst;Temperature;Pressure;

Steps:

1-10 Example 4

In the 8000l stainless steel reaction kettle, drop into 4000kg of ethyl n-propyl ether, 1000kg of trifluoromethylbenzene, 472kg of acetic acid, 30kg of tetrabutylammonium bromide, 6kg of sodium tert-butoxide, pressurized with nitrogen gas 0.5-0.6MPa, and heated up with stirring. Reaction at 65-75°C for 9 hours,Cool to normal temperature, add 300kg of water for washing, stand for stratification, separate the water phase, and the oil phase is subjected to vacuum distillation to remove ethyl n-propyl ether,The weight of m-trifluoromethyl acetophenone is 1232 kg, the content is 99.6%, and the yield is 96.3% in terms of trifluoromethyl benzene.

References:

CN113956143,2022,A Location in patent:Paragraph 0035-0054

401-78-5 Synthesis