ChemicalBook CAS DataBase List 3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-

3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)- synthesis

11synthesis methods

Product Name:3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-
CAS Number:342417-01-0
Molecular formula:C18H22N4O
Molecular Weight:310.39

881743-64-2 Synthesis

3-PYRIDINECARBOXAMIDE, N-(1,1-DIMETHYLETHYL)-4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-

881743-64-2
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3-PYRIDINECARBOXAMIDE, 4-(2-METHYLPHENYL)-6-(4-METHYL-1-PIPERAZINYL)-

342417-01-0
147 suppliers
$5.00/100mg

Yield:342417-01-0 88%

Reaction Conditions:

with methanesulfonic acid at 400; for 5 h;

Steps:

1 Synthesis of intermediate A-4
Intermediate A-3 (582 mg, 1.625 mg) was dissolved in 10 ml of methanesulfonic acid and warmed to 100 ° C for 5 h. The reaction solution was poured into ice water and extracted with methyl tert-butyl ether.After the organic phase was combined, it was washed twice with water, the aqueous layer was combined, and the pH was adjusted to 14 with NaOH, and then extracted with methyl tert-butyl ether. The second organic layer was combined, washed successively with water, saturated brine, anhydrousDry over sodium sulfate.Pressurized distillation,The intermediate A-4 was purified to give a yield of 88%.

References:

Beijing Kuanhou Pharmaceutical Technology Co., Ltd.;Cui Yimin;He Long;Ouyang Liang;Gou Maling;Wang Ling CN109384712, 2019, A Location in patent:Paragraph 0107; 0109; 0118; 0119

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109-01-3 Synthesis