ChemicalBook CAS DataBase List 4,5-Imidazoledicarboxylic acid

4,5-Imidazoledicarboxylic acid synthesis

9synthesis methods

Product Name:4,5-Imidazoledicarboxylic acid
CAS Number:570-22-9
Molecular formula:C5H4N2O4
Molecular Weight:156.1

51-17-2 Synthesis

51-17-2
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570-22-9
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$10.00/5g

Yield:570-22-9 73%

Reaction Conditions:

with Iron(III) nitrate nonahydrate;tetrabutylammomium bromide;nitric acid in water at 80; for 8 h;

Steps:

18.1-18.3; 19.1-19.3; 22.1-22.3; 23.1-23.3; 24.1-24.3 Example 19
(1) Put 30 g of water into the reaction kettle, turn on the stirring, and sequentially add 0.06 g of Fe (NO3) 3.9H2O, 15 g of 96% sulfuric acid, 0.03 g of tetrabutylamine bromide, 2.5 g of benzimidazole, and raise the temperature;(2) When the reaction temperature reaches 80 ° C, 20 g of oxone is added in batches, and the reaction is incubated for 8 hours after the addition.(3) After the reaction is completed, the temperature is lowered to -10 to 10 ° C, and concentrated ammonia is slowly added dropwise under stirring to adjust the pH value to 0.6 to 1, and then stirring is continued for 1 hour for crystallization, suction filtration, and drying to obtain 4,5-imidazole di Carboxylic acid, the filtrate can be used for further product recovery, yield 73%.

References:

Changshu Institute of Technology;Yang Yang;Fu Renzhong;Wang Xin;Fang Zhengjiao;Lu Zhengyi;Zeng Xiaojun CN110818628, 2020, A Location in patent:Paragraph 0133-0140; 0149-0160

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