ChemicalBook CAS DataBase List 7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine

7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine synthesis

6synthesis methods

Product Name:7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine
CAS Number:1770840-43-1
Molecular formula:C6H5IN4
Molecular Weight:260.04

159326-68-8 Synthesis

159326-68-8
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7-Iodopyrrolo[2,1-f][1,2,4]triazin-4-amine

1770840-43-1
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Yield:1770840-43-1 95%

Reaction Conditions:

with N-iodo-succinimide in N,N-dimethyl-formamide at 0; for 1 h;

Steps:

Synthesis of iodinated intermediates of formula (I) (ie X in formula (I) is iodine):

In a 1000 ml round bottom flask, 40 g of the triazineamine compound of formula (V) obtained above and 200 ml of DMF were added. After the resulting mixture was cooled to 0°C, 70 g of N-iodosuccinimide was added at once, and the reaction was magnetically stirred for 1 hour. After that, the resulting reaction mixture was poured into 500 mL of 1 M NaOH aqueous solution, and a large amount of pale white precipitate was generated. Finally, suction filtration was performed, and the filter residue was washed with water and dried over anhydrous sodium sulfate to obtain a high-purity iodinated intermediate compound of formula (I) (yield: about 95%).

References:

CN111233870,2020,A Location in patent:Paragraph 0062-0063