ChemicalBook CAS DataBase List 4'-AMINOBUTYROPHENONE

4'-AMINOBUTYROPHENONE synthesis

10synthesis methods

Product Name:4'-AMINOBUTYROPHENONE
CAS Number:1688-71-7
Molecular formula:C10H13NO
Molecular Weight:163.22

64-17-5 Synthesis

64-17-5
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$10.00/50g

100-19-6
303 suppliers
$5.00/5g

1688-71-7
54 suppliers
$30.00/500mg

99-92-3 Synthesis

99-92-3
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$6.00/10g

Yield: 21 %Chromat. ， 69 %Chromat.

Reaction Conditions:

with sodium hydroxide at 120; for 24 h;

Steps:

Reduction and chain elongation
General procedure: A mixture of 4-nitroacetophenone (0.83 g,5 mmol), NaOH (0.6 g), Pd/MgLaO (0.2 g) and the appropriate alcohol (10 ml)were stirred at 120 C (bath temperature) for 24 h. The mixture was filtered,the solid was washed with MeOH and the filtrate was concentrated in vacuum.The residue was dissolved in Et2O and H2O. Dilute HCl (25%) was added untilpH 1. The two phases were separated and the aqueous phase basified to pH 8by adding NaHCO3. The aqueous phase was extracted with Et2O (2 50 mL).The organic phase was dried over Na2SO4 and concentrated in vacuum. Theproducts were purified by column chromatography

References:

Németh, János;Kiss, Árpád;Hell, Zoltán [Tetrahedron Letters,2013,vol. 54,# 45,p. 6094 - 6096]