ChemicalBook CAS DataBase List 4-Aminophenol

4-Aminophenol synthesis

14synthesis methods

Product Name:4-Aminophenol
CAS Number:123-30-8
Molecular formula:C6H7NO
Molecular Weight:109.13

Conventionally 4-aminophenol was manufactured using iron-acid reduction of p-nitrobenzene. Reduction using iron-acid is a multi-step process. The modern method is the catalytic dehydrogenation of nitrobenzene to 4-aminophenol using a noble metal catalyst in the presence of an acidic medium. This method also produces aniline as a side-product. The advantage of a reduction using a noble metal catalyst is that it involves a single step reaction, an environment friendly and more efficient process, as there is no evolution of an environmentally harmful gas. Moreover, the side-product aniline is also a valuable chemical.

synthesis of 4-aminophenol

36309-42-9
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123-30-8
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Yield:123-30-8 98%

Reaction Conditions:

with methanol;1,3-disulfonic acid imidazolium hydrogen sulfate at 20; for 0.0666667 h;Green chemistry;

Steps:

General procedure for the deprotection of trimethylsilyl ethers

General procedure: A mixture of the substrate (1 mmol), ionic liquid [Dsim]HSO4 (6.5 mg, ～0.02 mmol) in methanol (2 mL) was stirred at room temperature. After completion of the reaction (monitored by TLC), solvent was evaporated, water (1 mL) was added to the mixture, and stirred vigorously. Decantation of the mixture gave almost pure product(s). The products were characterized by comparison of their IR and NMR data. The ionic liquid was dried at 65 ?C under vacuum to remove moisture, and then reused.

References:

Shirini, Farhad;Khaligh, Nader Ghaffari;Akbari-Dadamahaleh, Somayeh [Journal of Molecular Catalysis A: Chemical,2012,vol. 365,p. 15 - 23]

89415-43-0
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123-30-8
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References

24541-43-3
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123-30-8
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References

100-02-7 Synthesis

100-02-7
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123-30-8
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References

98-95-3
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123-30-8
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62-53-3 Synthesis

62-53-3
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References

4-Aminophenol Related Search:

Tris(hydroxymethyl)aminomethane Acetaminophen Glycine 6-Aminocaproic acid Phenol 4-Aminophenylacetonitrile 4-Aminobenzoic acid Sulfanilamide p-Aminobenzamide 4-Aminosalicylic acid