ChemicalBook CAS DataBase List 4-chloro-3-(pyridin-2-yl)aniline

4-chloro-3-(pyridin-2-yl)aniline synthesis

11synthesis methods

Product Name:4-chloro-3-(pyridin-2-yl)aniline
CAS Number:879088-41-2
Molecular formula:C11H9ClN2
Molecular Weight:204.66

879088-40-1 Synthesis

879088-40-1
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879088-41-2
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Yield: 96%

Reaction Conditions:

with iron hydroxide oxide;pyrographite;hydrazine hydrate in methanolReflux;Reagent/catalyst;

Steps:

4 Preparation of 4-chloro-3-(pyridin-2-yl)aniline
To a 100ml volumetric flask 20mmol 2-(2-chloro-5-nitrophenyl)pyridine, 50ml of methanol, 1g of activated carbon, 2mmol FeOOH and 60mmol 85% hydrazine hydrate was heated to reflux and stirred for 6 ~ 8h, after completion of the reaction, was filtered, spin-dry The solvent was dissolved with 150ml of dichloromethane, the organic phase was washed with saturated sodium bicarbonate solution (20ml×3), the organic phase was dried under reduced pressure. Distillation to give crude product was recrystallized from n-propanol to give a pale yellow solid, yield 96%.

References:

Zhengda Tianqing Pharmaceutical Group co., LTD.;Suzhou Dongnan Drug Development co., LTD;LI, RUI;GU, HUI LONG;ZHAO, HU CHENG;LIU, FEI;WANG, XIAO NING;SUN, JIAN CN103910671, 2016, B Location in patent:Paragraph 0119; 0120; 0121