ChemicalBook CAS DataBase List 4-FLUOROBENZOIC ANHYDRIDE

4-FLUOROBENZOIC ANHYDRIDE synthesis

6synthesis methods

Product Name:4-FLUOROBENZOIC ANHYDRIDE
CAS Number:25569-77-1
Molecular formula:C14H8F2O3
Molecular Weight:262.21

456-22-4 Synthesis

456-22-4
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$10.00/100 g

25569-77-1
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$13.00/250mg

Yield:25569-77-1 95%

Reaction Conditions:

with potassium carbonate;p-toluenesulfonyl chloride in acetonitrile at 20; for 2.5 h;

Steps:

3.2. General Procedure for the Preparation of CarboxylicAcid Anhydride Using TsCl in Conventional System
General procedure: TsCl (0.5 mmol, 0.10 g) was added to the mixture of carboxylic acid (1 mmol) and K₂CO₃ (1.5 mmol, 0.20 g) in dry CH₃CN (5 mL), the reaction mixture was stirred at roomtemperature for the appropriate time (20-180 min, Table 2) until the TsCl was no longer detectable by TLC. After the completion of the reaction, CH₂Cl₂ or Et₂O (2×10 mL) was added to the reaction mixture, stirred, filtered, and the organic layer was dried over CaCl₂. The evaporation of the solvent afforded a highly pure product.

References:

Eskandari, Parvin;Kazemi, Foad [Letters in Organic Chemistry,2017,vol. 14,# 6,p. 431 - 439]

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