4-Fluorophenylacetic acid synthesis
- Product Name:4-Fluorophenylacetic acid
- CAS Number:405-50-5
- Molecular formula:C8H7FO2
- Molecular Weight:154.14
766-98-3
243 suppliers
$6.00/1g
405-50-5
418 suppliers
$5.00/10g
Yield:405-50-5 747.6 mg
Reaction Conditions:
Stage #1:1-ethynyl-4-fluorobenzene with n-butyllithium in tetrahydrofuran at -78; for 1 h;
Stage #2: with 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran for 2 h;
Stage #3: with oxone in acetone at 50; for 12 h;
Steps:
18 Example 18
At -78 ° C, n-butyllithium (2.4 mL, 2.5 mol / L, 1.2 equivalents) was added dropwise to a solution of 4-fluorophenylacetylene (600.7 mg, 1.0 equivalent) in a tetrahydrofuran solution (15 mL) for 1 h. Isopropanol pinacol borate (1.2 mL, 1.2 equivalents) was added dropwise to the mixed solution, and the reaction was continued for 2 hours. A 1,4-dioxane solution of hydrogen chloride (1.9 mL, 4 M in dioxane, 1.5 equivalents) was added. After quenching, the reaction was warmed to room temperature. After rotary evaporation of the solvent, it was prepared into an acetone solution (0.3M), and then potassium peroxymonosulfonate solution (0.5M, 4.6107g, 1.5 equivalents) was added, and transferred to 50 ° C and stirred for 12h After separation and purification, 747.6 mg of 4-fluorophenylacetic acid with a purity of 97% was obtained.
References:
Hunan University;Zhao Wanxiang;Li Ruoling;Li Chenchen;Zhao Pei CN110330420, 2019, A Location in patent:Paragraph 0118-0123
34837-84-8
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$10.00/1g
405-50-5
418 suppliers
$5.00/10g
587-88-2
95 suppliers
$6.00/1g
405-50-5
418 suppliers
$5.00/10g