ChemicalBook CAS DataBase List 4-FLUOROPHENYLMAGNESIUM BROMIDE

4-FLUOROPHENYLMAGNESIUM BROMIDE synthesis

6synthesis methods

Product Name:4-FLUOROPHENYLMAGNESIUM BROMIDE
CAS Number:352-13-6
Molecular formula:C6H4BrFMg
Molecular Weight:199.3

460-00-4 Synthesis

460-00-4
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$6.00/10g

352-13-6
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$40.00/50 mL

Yield:-

Reaction Conditions:

with iodine;magnesium in tetrahydrofuran at 68 - 70; for 1.5 h;Heating / reflux;

Steps:

1 1) 20% solution of 4-fluorophenylmagnesium bromide in tetrahydrofuran
53.5 g of magnesium turnings (2.2 mol) and 0.3 g of iodide are charged into a 4-litres reactor at room temperature under nitrogen. The mixture is then heated to 70°C and a solution of 369.5 g (2.11 mol) of 4-fluorobromobenzene in 1960 ml tetrahydrofuran (5.3 volumes on 4-fluorobromobenzene) is added drop wise, in one hour. After addition the mixture is heated to reflux temperature (68÷70°C) for 30 minutes, then it's cooled to 25°C. 2000g of a 20% solution of 4-fluorophenylmagnesium bromide in tetrahydrofuran are obtained (to be kept under nitrogen and protected from the light).

References:

Adorkem Technology SpA EP1506963, 2005, A1 Location in patent:Page/Page column 4

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