ChemicalBook CAS DataBase List 4-Methoxybenzylchloride

4-Methoxybenzylchloride synthesis

13synthesis methods

Product Name:4-Methoxybenzylchloride
CAS Number:824-94-2
Molecular formula:C8H9ClO
Molecular Weight:156.61

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Yield:824-94-2 99%

Reaction Conditions:

with oxalyl dichloride;1-methyl-3-(2-(3-methyl-2-oxoimidazolidin-1-yl)ethyl)-1H-imidazol-3-ium hexafluorophosphate at 20 - 60; for 24 h;Reagent/catalyst;

Steps:

Chlorination of Alcohols (Table 2); General Procedure

General procedure: The solution of ionic-liquid-supported DMI 7 (2.2 mmol) in[bmim]PF6 (2 mL) was added to oxalyl chloride (2.0 mmol), andthe mixture was stirred at 60 °C for 2 h. The mixture was then added to the appropriate alcohol (1.5 mmol), and the resultingmixture was stirred at r.t. overnight. Finally, the mixture wasextracted with hexane 10 mL x 3, and the organic layer wasconcentrated.

References:

Koguchi, Shinichi;Shibuya, Yuga;Igarashi, Yusuke;Takemura, Haruka [Synlett,2019,vol. 30,# 8,p. 943 - 946] Location in patent:supporting information

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