ChemicalBook CAS DataBase List 4-(MethoxyMethoxy)benzoicacid

4-(MethoxyMethoxy)benzoicacid synthesis

10synthesis methods

Product Name:4-(MethoxyMethoxy)benzoicacid
CAS Number:25458-44-0
Molecular formula:C9H10O4
Molecular Weight:182.17

139884-19-8
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37174-65-5
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Yield:37174-65-5 94%

Reaction Conditions:

with lithium hydroxyde monohydrate;water monomer in 1,4-dioxane;methanol at 0 - 20; for 5 h;Inert atmosphere;

Steps:

2.2.7; 3.3.1.3 Preparation of Compound Int-TG4

To a solution of compound Int-TG4-2 (1.14 g, 5.81 mmol) in methanol/H₂0/l,4-dioxane (16.0 mL/ 8.0 mL/ 16.0 mL) was added lithium hydroxide monohydrate (975 mg, 23.2 mmol) at 0 °C under N2 atmosphere. The reaction mixture was stirred at room temperature for 5 h. The reaction was quenched with 2N HCl and extracted with EtOAc. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The compound Int-TG4 was used in the next step without further purification. (995 mg, 94%)¹H NMR (400 Hz, MeOH-D₄) δ 7.96 (d, J= 8.8 Hz, 2H), 7.08 (d, J= 8.8 Hz, 2H), 5.25 (s, 2H), 3.55 (s, 3H)

References:

WO2021/260438,2021,A1 Location in patent:Page/Page column 123; 128-129; 131-132

6515-21-5 Synthesis