4-Methylbenzhydrol synthesis
- Product Name:4-Methylbenzhydrol
- CAS Number:1517-63-1
- Molecular formula:C14H14O
- Molecular Weight:198.26
108-86-1
496 suppliers
$10.00/5g
104-87-0
506 suppliers
$6.00/25g
134-84-9
467 suppliers
$7.00/10g
1517-63-1
118 suppliers
$63.00/1g
Yield:1517-63-1 90% ，134-84-9 5%
Reaction Conditions:
with nickel(II) bromide dimethoxyethane;zinc;1,2-bis-[(2,6-diisopropylphenyl)imino]acenaphthene in tetrahydrofuran at 70; for 24 h;
Steps:
Synthesis of benzhydrols by the reaction between aryl halide and benzaldehyde (general procedure)
General procedure: Activated zinc (75 mg, 1.15 mmol), NiBr2(DME) (15.4 mg, 0.05 mmol), and ligand L12 (0.05 mmol) were placed into a 8-mL glass vial using an atmosphere controlled glove box. Then, 0.2 M solution of benzaldehyde (5 mL, 1 mmol) in THF and aryl halide (1.15 mmol) were added to this mixture. The reaction mixture was magnetically stirred at 70 °C, the target product was isolated from the reaction mixture by column chromatography on silica gel 60 Å (40-63 um).
References:
Asachenko;Valaeva;Kudakina;Uborsky;Izmer;Kononovich;Voskoboynikov [Russian Chemical Bulletin,2016,vol. 65,# 2,p. 456 - 463][Izv. Akad. Nauk, Ser. Khim.,2016,# 2,p. 456 - 463,8]
5908-41-8
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15738-23-5
26 suppliers
$128.00/500 mg
1517-63-1
118 suppliers
$63.00/1g