4-Methylimidazole synthesis
- Product Name:4-Methylimidazole
- CAS Number:822-36-6
- Molecular formula:C4H6N2
- Molecular Weight:82.1
Yield:822-36-6 94.5%
Reaction Conditions:
with ammonia at 170; under 45004.5 Torr; for 0.1 h;Temperature;Pressure;
Steps:
1; 1-7 Example 2
The liquid ammonia was pumped at a flow rate of 6.5L/min into the channel reactor of the microchannel reactor and the pipeline reactor in series with a total liquid holding capacity of 100L purchased from Shandong Haomai Machinery Manufacturing Co., Ltd.,The pressure in the control channel reactor was maintained at 6MPa, in hydroxyacetone:Under the molar ratio of formamide=1:6, hydroxyacetone and formamide were pumped into the channel reactor with a hydroxyacetone flow rate of 3.15L/min and a formamide flow rate of 10.35L/min respectively, and the reaction temperature was 170°C, stay in the reactor for 6 min,Then the reaction liquid flows into the gas-liquid separator (Beijing Century Senlang Experimental Instrument Co., Ltd., specification 2L) after gas-liquid separation, the conversion rate of hydroxyacetone is 99.4% after detection,4-methylimidazole selectivity was 96.1%,After post-treatment, the yield of 4-methylimidazole was 94.5%, which was 13.5% higher than that of Comparative Example 1.
References:
CN114276299,2022,A Location in patent:Paragraph 0056-0074
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