ChemicalBook CAS DataBase List (4'-O-methyl)methyl gallate

(4'-O-methyl)methyl gallate synthesis

12synthesis methods

Product Name:(4'-O-methyl)methyl gallate
CAS Number:24093-81-0
Molecular formula:C9H10O5
Molecular Weight:198.17

149-91-7 Synthesis

149-91-7
676 suppliers
$5.00/25g

74-88-4
341 suppliers
$15.00/10g

1916-07-0 Synthesis

1916-07-0
424 suppliers
$6.00/25g

24093-81-0
48 suppliers
$45.00/10mg

83011-43-2 Synthesis

83011-43-2
125 suppliers
$50.00/250mg

Yield:24093-81-0 61% ，83011-43-2 14% ，1916-07-0 10%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 0 - 20;

Steps:

General procedure of methylation of gallic acid
General procedure: To the gallic acid solution in DMF at 0° C,K2CO3 and MeI were added. The reaction mixture is stirred at 0°C and allowed to reach at room temperature overnight, with a total reaction time of 18-24 hours. The reaction mixture is then diluted byaddition of ethylacetate, and washed repeatedly with saturated NaHCO3 solution. The ethylacetate phase is then washed further with a saturated NaCl(Brine) solution to withdraw residual water, then dried with anhydrous MgSO4, filtered, and concentrated, resulting in a crude extract of methylated product. Furthermore, the crude extract is purified by silica gel chromatography column. Pure compounds were analyzed by Thin Layer Chromatography (TLC), Nuclear Magnetic Resonance Spectrometer, and High Resolution Mass Spectrometer

References:

Arsianti, Ade;Astuty, Hendri;Fadilah;Simadibrata, Daniel Martin;Adyasa, Zoya Marie;Amartya, Daniel;Bahtiar, Anton;Tanimoto, Hiroki;Kakiuchi, Kiyomi [Oriental Journal of Chemistry,2018,vol. 34,# 2,p. 655 - 662]

99-24-1 Synthesis