5-(4-NITRO-PHENYL)-2H-TETRAZOLE synthesis
- Product Name:5-(4-NITRO-PHENYL)-2H-TETRAZOLE
- CAS Number:16687-60-8
- Molecular formula:C7H5N5O2
- Molecular Weight:191.15
1129-37-9
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$18.00/1g
16687-60-8
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$15.00/100mg
Yield: 85%
Reaction Conditions:
with sodium azide;copper(II) ferrite in N,N-dimethyl-formamide at 120; for 12 h;Sealed tube;
Steps:
General Procedure for the Synthesis of 5-substituted 1H-tetrazoles
General procedure: A mixture of oxime (1 mmol), NaN3 (1.5 mmol), catalyst(30 mol %) and DMF (3 mL) was taken in a sealed tube and stirred at 120 °C for 12 h. After completion of the reaction,the catalyst was separated from the reaction mixture with an external magnet kept at RT for 5 min. Then H2O (5 mL) and3N HCl (5 mL) were added, and an extraction with ethylacetate was performed. Resultant organic layer was washedwith water, dried over sodium sulfate, and the solvent was removed by distillation. The crude material was purified by column chromatography on silica gel (hexane/AcOEt 1:1)and afforded the pure tetrazole derivatives.
References:
Akula, Ravi Kumar;Adimulam, Chandra S.;Gangaram, Sathaiah;Kengiri, Raju;Banda, Narsaiah;Pamulaparthy, Shanthan R. [Letters in Organic Chemistry,2014,vol. 11,# 6,p. 440 - 445]
1129-37-9
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$18.00/1g
16687-60-8
90 suppliers
$15.00/100mg
619-72-7
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$11.00/1g
16687-60-8
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555-16-8
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$5.00/5g
16687-60-8
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26060-30-0
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$25.00/1g
16687-60-8
90 suppliers
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