ChemicalBook CAS DataBase List 5-AMINO-3-PHENYLPYRAZOLE

5-AMINO-3-PHENYLPYRAZOLE synthesis

11synthesis methods

Product Name:5-AMINO-3-PHENYLPYRAZOLE
CAS Number:827-41-8
Molecular formula:C9H9N3
Molecular Weight:159.19

614-16-4 Synthesis

614-16-4
257 suppliers
$17.00/5g

827-41-8
91 suppliers
$9.00/250mg

Yield: 99%

Reaction Conditions:

with hydrazine hydrate in methanol at 150; for 0.0833333 h;Microwave irradiation;Temperature;Time;Solvent;

Steps:

1.2. General procedure of microwave synthesis of pyrazoles
General procedure: A microwave tube was charged with ketonitrile (2.0 mmol), methanol (1 mL), and hydrazine monohydrate (2.6 mmol) and subjected to microwave irradiation (100 W, 150 °C) for 5 minutes. Volatiles were subsequently removed under reduced pressure. The residue was purified by either trituration with cold methanol or cyclohexane, or by using column chromatography to give the final product.

References:

Kelada, Mark;Walsh, John M. D.;Devine, Robert W.;McArdle, Patrick;Stephens, John C. [Beilstein Journal of Organic Chemistry,2018,vol. 14,p. 122 - 1228] Location in patent:supporting information

614-16-4 Synthesis

614-16-4
257 suppliers
$17.00/5g

80-17-1 Synthesis